The inferior alveolar nerve (IANB) block is the most frequently used technique for mandibular anesthesia. Difficulty experienced in obtaining satisfactory anesthesia after (IANB), remains a common clinical problem. So we decided to conduct a prospective, double blind, randomized study to compare the success of inferior alveolar nerve blocks based on experience of operator in patients requiring mandibular teeth extraction. Materials and Methods: A prospective, double blind, randomized, single center study was conducted amongst 50 patients requiring extraction of mandibular teeth. Random allocation of patients was done using computer–generated randomization chart into three groups’ i.e. Undergraduate trainees, house surgeons and Staff. Following things were assessed:– efficacy of anesthesia, onset of anesthesia and complications. Data on 100 subjects was entered in Microsoft excel & subjected to statistical analysis using SPSS version–11 statistical package. Result: The success of anesthesia reported by the under graduates was 61%, House surgeons was 61.1% and staff was 75%. No statistical significant difference was found in the anesthetic success based on the experience of operator (p>0.05). The result of our study seems to suggest that the experience of operator does not have any effect on anesthetic efficacy and onset of anesthesia with inferior alveolar nerve blocks.