Sannipataj Jwara is the complex ailment in which pathogenesis and severity of symptoms become progressed and challenging to cure. According to Acharya Madhav, symptoms of Pittoulbana Sannipataj Jwara closely resemble with Typhoid fever. We are facing an actual prospective with Typhoid fever that Antibiotic resistance and relapse. The study is needed to provide Ayurvedic interventions which will help in the prevention of further complications, its relapse and side–effects of different Antibiotics. To achieve the objective total patients of 50 having chief complaints of Pittoulbana Sannipataj Jwara were registered then, subjected to Widal Agglutination test. After analyzing the data statistically, it was found that with the increasing severity of the symptoms of Pittoulbana Sannipataj Jwara, the level of titres also increases with the advancement of the disease. Moreover, Pittoulbana Sannipataj Jwara can be co–related with Typhoid fever.