Background: The study was done to ascertain prevalence of unconjugated hyperbiliribnemia in asymptomatic healthy blood donors and review the literature about feasibility of utilizing blood components from those donors. Materials & Methods: This retrospective study was done for a period of 3 years. A total of 23,501 blood units were collected and all the units were subjected to mandatory transfusion transmitted screening. All the plasma and platelet concentrate bags which were icteric on visual inspection were subjected tonbiochemical investigations to rule out other causes of hyperbilirubinemia. Results: Among 23,501 units collected, 69 units (0.29 %) were icteric on visual inspection. All these units had unconjugated hyperbilirubinemia and tested negative for transfusion transmissible infections. Conclusion: As there are no studies to document the safety of the recipients receiving such abnormal colored plasma as well as to document the hazards in its transfusion, the question arises whether to transfuse such units or not. Majority of blood donors, whose plasma and platelets icteric, are aymptomatic. High colored plasma particularly unconjugated hyperbilirubinemia might suggest Gilbert’s syndrome or any underlying occult hepatitis infection. Proper guidelines are to be framed about the use and discarding of blood components in these donors.