This study was done to compare the block characteristics and analgesic duration of equal amount (32 ml ) of drug i. e 0.5% bupivacaine with either dexamethasone or clonidine for brachial plexus block by supraclavicular approach . In our randomized prospective double blinded study, we have evaluated the effects on onset and duration of sensory and motor block among 2 groups–Bupivacaine (0.5% 30 ml ) with Clonidine (150µg 1ml) and Bupivacine (0.5% 30 ml) with dexamethasone (8mg 2ml) in supraclavicular brachial plexus block named as Group BC and Group BD respectively. In each group volume was diluted upto 32 ml with normal saline. Dexamethasone and Clonidine both when added to bupivacaine in supraclavicular brachial plexus block enhanced the onset of sensory and motor block compared to control group, but was faster in Clonidine group in comparison to Dexamethasone group. Similarly, the duration of sensory and motor block was significantly prolonged in Clonidine group than Dexamethasone group. The time for rescue analgesia was prolonged in both groups of patients receiving Clonidine and Dexamethasone, but it was more prolonged in patients receiving Clonidine. Clonidine produces some side effects (bradycardia) intraoperatively but that was manageable whereas dexamethasone produces minimal side effects and is relatively safer.