Nobel sweeteners can be used for caries protection, nutritional values and economic basis. A strong relation exists between diet and oral health across the life span. Dietary behaviour is determined by community, family and individual factors. Excessive sugar consumption is associated with increased risk of caries, cardiovascular disease, Diabetes mellitus, metabolic syndrome, nonalcoholic fatty liver disease and obesity etc. Clinicians and parents should encourage children in early experience with healthy food habits. Novel sweeteners can be used instead of sugar to the children for healthy eating behaviour and development. This study aimed to search and collect scientific evidence to use novel sweeteners to live healthy life. It is essential to adopt a scientific attitude towards novel sweeteners to open a new knowledge.