Aim: To analyse facial soft tissue thickness from lateral cephalogram in young adults and to correlate possible variation with gender and skeletal classes Material and method: This study was conducted in the Department of Oral Medicine and Radiology among 54 pretreatment lateral cephalograms of adult male and female subjects between 18 to 25 years with different sagittal skeletal malocclusion. Using a millimeter ruler the facial soft tissues thickness were measured to the nearest 0.5 mm at 11 points: Glabella, Nasion, Rhinion, Subnasale, Labrale superius, Stomion, Labrale inferius, Labiomentale, Pogonion, Gnathion and Menton. After adding magnification factor to the obtained linear measurements final values were recorded and were entered into an Excel spreadsheet. Results: Mean facial soft tissue thickness was found to be greater for males as compared to female subjects at all the points. However, statistically significant difference was observed at points Rhinion, Subnasale, Labrale superius, Labrale inferius and Labiomentale in skeletal Class I. In skeletal class II difference were found at Nasion, Subnasale, Labrale superius, Labrale inferius. Conclusion: Facial soft tissue thickness varies considerably among different population groups, sex and sagittal relationship of jaws.