Cardiovascular diseases (CVD’s) is one of the leading cause of deaths in India & worldwide. Potential cardiovascular risk factor could be hypertension, diabetes, stroke etc. The increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this study we have analyzed oxidative stress marker (FRAP), endogenous antioxidants level (albumin, uric acid and Bilirubin), Lipid profile, cardiac marker (CK–MB, LDH & AST) in patients with CVDs. FRAP & HDL cholesterol and albumin were significantly decreased in study group. The lipid profile and cardiac markers were significantly increased in study group. No significant changes were observed in uric acid and bilirubin levels. It was concluded that increased oxidative stress, abnormal cardiac markers and lipid profile were the risk factors in CVD‘s.