The majority of periodontal diseases are caused due to inflammation initiated by accumulation of microbes in the plaque. When this continues, this plaque reaches subgingivally and it becomes difficult for the patient to remove it by conventional brushing. The treatment option available in such scenario is mechanical debridement of the deposits. But in cases of complex root anatomy or apically placed lesion, a clean environment free of microbes and deposits cannot be ensured. Thus we need to search for other methods of mechanical debridement in such situations.One of the effective treatments is the local drug delivery or site specific delivery of drug. In this treatment method, the antibiotic in sufficient concentration reaches the depth of the pocket. In this article; the authors have reviewed the applications of local drug delivery in the management of periodontal diseases.