IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-1-9808 Original Research Paper Radiological and Electrophysiological Abnormalities in children presenting with afebrile seizures in a tertiary care centre K.Umamaheswara Rao Dr. January 2017 6 1 01 02 ABSTRACT

 BACKGROUND: The present study aims at determining the frequency of radiological (Neuroimaging) and electrophysiological (EEG) abnormalities in children admitted with afebrile seizures and also to determine the most common cause of these abnormalities. METHODOLOGY: The present study included 96 children presenting with afebrile seizures between the age groups of 2months to 10 years admitted to PICU, Pediatric department of Alluri Sitarama Raju Academy of Medical Sciences Hospital, Eluru, during the period of two years from Dec 2014 to Sep 2016. Seizures were classified based on latest terminology laid by ILAE (Berg et al.)1 2010. All the children were subjected to EEG and either CT/MRI (with or without contrast) or both. The subsequent findings helped in determining the cause of afebrile seizures. RESULTS: Afebrile seizures were more commonly found in males when compared to females. Higher percentage of children in the present study group hailed from rural areas which were resource limited. 42.7% of the study group belonged to the age group of 6months– 4 years. In the age groups 6months– 4yrsand 4–6yrs GTCS was most common. whereas between 6–8yrs, and 8–10yrs Focal seizures were more common. The frequency of radiological (Neuroimaging) abnormalities was determined to be 76%. which indicates that Neuroimaging is necessary in afebrile seizures. Most common cause of radiological (Neuroimaging) abnormalities was determined as Cerebral Palsy 59.4%, followed by Neurocysticercosis 11.4%. Cortical Atrophy was the most common radiological abnormality observed in children with Cerebral Palsy. In Neurocysticercosis  single lesions (91%) were most commonly observed. The Frequency of EEG abnormalities in the present study was  53.2%. of In  cases  presenting with GTCS, EEG abnormalities were observed in 73.4%  followed by Focal seizure with impairment of consciousness 37.9%. Different patterns of EEG observed were: Generalized epileptiform discharge (68.6%), Focal epileptiform discharge (25.4%), Multifocal  (4%), Others (Burst Suppression) (2%). Cerebral palsy and Neurocysticercosis were determined to be one of the common causes of acquired epilepsy. Most common Cause of Radiological (Neuroimaging) and Electrophysiological Abnormalities was Cerebral Palsy (84.3%) and the 2nd most common was Neurocysticercosis (2.6%). CONCLUSION: Radiological (Neuroimaging) And Electrophysiological(EEG) abnormalities are common in afebrile Seizures. Eitiology of afebrile seizure are (Neuroinfections, Neurocysticercosis, Metabolic causes, Neurotrauma following Adverse perinatal events (Birth Asphyxia) etc) Most of these are treatable (like Neuroinfections, Neurocysticercosis). ) and are easily picked up in Neuroimaging. Future epilepsy can be predicted by EEG as it proved to be a sensitive modality in picking up abnormalities and treatment can be accordingly given.