The aim of this study was to investigate the Prevalence of  Hyperprolactinemia and Hypothyroidism in patients diagnosed as  Benign breast disease.  A Prospective study was done for 100 patients who were diagnosed as Benign breast disease and serum Prolactin and TSH( Thyroid stimulating hormone) & T4( Thyroxine) levels estimation was done for a period of one year.

 It could be end organ hypersensitivity to normal circulating levels of Prolactin that is responsible for benign breast disease and pharmacological manipulation of Prolactin in patients having raised serum levels can provide relief from symptoms.

          Both normal and pathological breast tissue exhibit high concentrations of

sodium iodide sypmorter(NIS), peroxidase and deiodinase indicating active

involvement of breast tissue in iodine metabolism. Our study strengthens the

association of thyroid dysfunction with benign breast disease. Hence Benign

breast disease patients should be screened for hypothyroidism and simple correction of Hypothroidism may result in significant clinical improvement.