An in–vitro study was done to compare canal transportation and centering ability of Rotary HyflexCM, WaveOne, Twisted files using Cone Beam Computed Tomography (CBCT) in curved root canals. Mesiobuccal roots from maxillary molars having atleast 15º curvature were allocated into three groups (n=10). In first group Rotary HyflexCM, in second, WaveOne and in third, Twisted files were used for canal preparation. Pre–instrumentation and post–instrumentation images were obtained at three levels  2, 3 and 4 mm above the apical foramen were compared and assessed using CBCT for determining the root canal shape. Statistical analysis was performed using One–Way ANOVA followed by Post–HOC test. P–value <0.05 was considered significant. HyflexCM maintained the canal curvature with minimal deviation in comparison to WaveOne and Twisted files systems with significant difference (P = 0.00). HyflexCM files showed lesser transportation and better centering ability than WaveOne followed by Twisted files.