Background–Congenital heart disease (CHD) is common entity seen in Down syndrome (DS). Approximately 40 to 60% of children with DS have heart defects and among those with CHD, 4–10% are associated with DS. Therefore Down syndrome patients are routinely advised echocardiography (ECHO) to rule out CHD. Material and method–This is a prospective hospital based study, over a period of two years. Confirmed Down syndrome patients having congenital heart disease were included in this study. The age and sex of patients, age of the mother, their extra cardiac anomalies and type of cardiac defects confirmed by echocardiography were documented and analysed. Observation–Echocardiography was done in 65 confirmed cases and among them 36(54.55%) had some form of congenital heart disease. This study showed that the most common form of CHD in these Down’s children was Ventricular Septal Defect (VSD) (25%) followed by Atrial Septal Defect (ASD) (22.2%). Patent ductus arteriosus (PDA) was seen in 7 cases (19.5%) and Tetrology of Fallot (TOF) was seen in 2 cases (5.5%). Conclusion–Fetal Echocardiography can be used as a screening tool for diagnosing Down’s syndrome baby having CHD in younger age group of mothers with high parity. All clinically suspected new born should undergone ECHO to exclude cardiac defects at the earliest to reduce morbidity and mortality.