High sensitive C–reactive protein (hs–CRP) is an established marker of low grade systemic inflammation. Nephropathy in type 2 diabetes mellitus (T2DM) develops due to chronic low grade inflammation and vascular endothelial dysfunction.  Microalbuminuria (MAU) is thought be a result of generalized damage of the endothelium in T2DM. Because hs–CRP and MAU seems to be closely related component of the same disease process, a strong relationship between these variables may be anticipated. The statistical analysis depicted a highly significant positive (r=0.506; p <0.001) correlation between hs–CRP and microalbuminuria. This data supports the hypothesis that inflammatory activities are involved in the pathogenesis of MAU.