ATTENUATION OF HEMODYNAMIC RESPONSE TO ENDOTRACHEAL EXTUBATION AFTER GENERAL ANAESTHESIA: A PROSPECTIVE RANDOMISED CONTROLLED STUDY OF TWO DIFFERENT INTRAVENOUS DOSES OF VERAPAMIL

Dr. Mumtaz Hussain; Dr Rajesh Kumar

Volume : VIII, Issue : VII, July - 2019

ATTENUATION OF HEMODYNAMIC RESPONSE TO ENDOTRACHEAL EXTUBATION AFTER GENERAL ANAESTHESIA: A PROSPECTIVE RANDOMISED CONTROLLED STUDY OF TWO DIFFERENT INTRAVENOUS DOSES OF VERAPAMIL

Dr. Mumtaz Hussain, Dr Rajesh Kumar

Abstract :

Like intubation, tracheal extubation are associated with significant hemodynamic changes resulting in transient increase in blood pressure and heart rate. A double blind randomized controlled study was conducted on 90 patients of ASA 1 and 2 undergoing elective surgery to compare the attenuation of hemodynamic responses to tracheal extubation by using either verapamil 0.05 mg/kg or 0.1mg/kg with a control group receiving saline only. On conclusion of surgery, the study drug was administered using double blind technique and residual muscle paralysis was reversed. The patient was extubated after 2 minutes of administering the study drugs. The haemodynamic parametes in the form heart rate (HR), systolic arterial pressure (SAP), diastolic blood pressure(DBP) and mean arterial pressure (MAP) were recorded during and after tracheal extubation. The result showed that both the doses of intravenous verapamil attenuated the increases in haemodynamic parameters. The attenuation was greatest with verapamil 0.1 mg/ kg, while the alleviative effect of verapamil 0.05mg/ kg was inferior. These findings suggest that a bolus injection of verapamil 0.1 mg/kg given 2 min before tracheal extubation is a more effective in attenuating the cardiovascular changes associated with extubation than 0.05mg/kg dose