Volume : VII, Issue : VI, June - 2018

Comparative efficacy of mono therapy of oral Itraconazole and oral Itraconazole with Isotretinoin in chronic and/or resistant superficial dermatophytosis

Dr Rashmi Arora, Dr Apeksha Solanki

Abstract :

Introduction– Superficial dermatophytosis such as Tinea corporis and tinea cruris are common in developing countries like India. Mono therapy with oral antifungals leads to partial clearance or relapse of lesions. Isotretinoin due to its keratolytic effect used as a an adjuvant to oral antifungals for recalcitrant dermatophytosis

 

Objectives– to compare the efficacy of mono therapy of oral antifungals and oral antifungals with isotretinoin in the treatment of recalcitrant superficial dermatophytosis

 

Methods– a pilot study of 76eleigible patients of KOH positive superficial dermatophytosis were allocated to two groups. Both groups were taking oral itraconazole 100mg BD with topical antifungals (Clotrimazole) for 15 days. After 2 weeksone group was continued with same line oftreatment and second group were received oral isotretinoin 0.3 – 0.4 mg/kg/day, In Adition   after Normal, baseline investigation.

After 2 weeks both groups were switched to only topical antifungal clotrimazole for additional 15 days to sustain the response. patients were followed up at 2, 4 and 6 months from baseline for signs of relapse.

 

Results–

Clinical cure and mycological cure from baseline were more significant in the group receiving both the drugs.

Conclusion– a 2 weekly course of isotretinoin can be an effective adjuvant to oral antifungals in treating recalcitrant superficial dermatophytosis.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Dr Rashmi Arora, Dr Apeksha Solanki, Comparative efficacy of mono therapy of oral Itraconazole and oral Itraconazole with Isotretinoin in chronic and/or resistant superficial dermatophytosis, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-6 | June-2018


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