Nephrotoxic changes induced by prenatal administration of Olanzapine in swiss albino mice

Dr.Soumya Khanna; Dr.Anand Mishra

Volume : VIII, Issue : VII, July - 2019

Nephrotoxic changes induced by prenatal administration of Olanzapine in swiss albino mice

Dr. Soumya Khanna, Dr. Anand Mishra

Abstract :

With the growing stress in lifestyle , women are becoming prone to develop mental illnesses, Psychiatric illness occurring during pregnancy if not treated may be associated with increased risks for mother ( including self harm/suicide, self neglect and reduced compliance with prenatal and postnatal care) and risks for the child ( impaired fetal development, infanticide and impaired mother child bonding). One such psychiatric illness is schizophrenia for which Olanzapine is given . This study aims to establish the safety profile of olanzapine on the kidney of fetus when given to pregnant mothers. Materials and methods : Olanzapine was given to pregnant mice in doses of 0.2mg/kg and 2mg/kg whereas tap water was given to control mice from 6th to 12th day of gestation. The female dams were sacrificed on 18th day of gestation by cervical dislocation and fetuses were dissected out by uterotomy. The kidney of mice emyos were dissected out, processed and were stained with H&E. Results : on histological examination , There is dose related damage of glomerulus and mesangial cells in cortex and degeneration and disruption of tubules in the medulla of fetal mice treated with Olanzapine Conclusion : Olanzapine causes a dose dependent damage to the fetal kidney when given to the mother during period of organogenesis