Volume : IX, Issue : VII, July - 2020

Oncolytic Viral Therapy - An Imminent Cancer Cure

Peoli Mukutawat, Bibhavendra Kumar Singh, Vivek Kaushal

Abstract :

Oncolytic virus therapy is the use of oncolytic viruses to kill cancer cells. Numerous clinical trials are under way using this approach. The use of viruses for cancer treatment is not new. Throughout the 20th century, case studies and small trials of various viruses in cancer therapy were reported. These trials used wild–type and crudely prepared viral isolates. It was in the 1990s that the era of genetic engineering of viruses to enhance their oncolytic potential began. The main focus was to identify viruses or their engineered variants with tumor–selective replication. However, it has always been appreciated that an immune component is important and may be critical for the therapeutic efficacy of this approach. Therapeutic efficacy of oncolytic virus therapy is achieved by a combination of selective tumor cell killing and establishment of anti–tumor immunity. Immune stimulation is caused by release of cell deis and viral antigens in the tumor microenvironment. Much research is required before the use of oncolytic viral therapy in clinics.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

ONCOLYTIC VIRAL THERAPY - AN IMMINENT CANCER CURE, Peoli Mukutawat, Bibhavendra Kumar Singh, Vivek Kaushal PARIPEX-INDIAN JOURNAL OF RESEARCH : Volume-9 | Issue-7 | July-2020

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