Volume : VI, Issue : VII, July - 2017

ORAL SUPPLEMENTATION WITH PROBIOTICS IN PREVENTION OF NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS WITH LOW BIRTH WEIGHT–A DOUBLE BLIND RANDOMIZED CONTROLLED STUDY

Annie Romell, Piyush Jain

Abstract :

 Background & Objectives

Necrotizing enterocolitis (NEC) is a devastating gastrointestinal (GI) disease that predominantly affects, preterm low birth weight (LBW) infants and its associated with high morbidity and mortality. Current evidence suggest that probiotics are effective in decreasing NEC in preterm infants. In this study the primary objective  was to study the role of oral probiotic supplementation to preterm infants in reducing incidence and severity of NEC.

 

Methods

Preterm infants <2 Kgs were studied and randomly assigned to case and control group. The case group received the supplements of probiotics  mixed with their feeds and the control group received only plain feeds without probiotics. The probiotic used was Lacfid sachets (1g containing 109 spores of Saccharomyces boulardi , Lactobacillus rhamanosus, Lactobacillus acidophilus, Lactobacillus sporogenes, Bifidobacterium bifidum, Bifidobacterium longum).The primary outcome was incidence and severity of NEC.

 

Results

The case and control groups did not differ significantly in the confounding factors and demographic and clinical variables. The incidence of NEC was 1.89% in test group and 6.38% in control group (p<0.05).2% babies developed stage 1 NEC,3% babies developed  stage 2 and 1% babies developed stage 3 disease. The incidence of sepsis in case group was 6.60% and 15.96% in control group (p<0.05).

Keywords :

NEC   Preterm   LBW   Probiotics  

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Annie Romell, Piyush Jain, ORAL SUPPLEMENTATION WITH PROBIOTICS IN PREVENTION OF NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS WITH LOW BIRTH WEIGHT–A DOUBLE BLIND RANDOMIZED CONTROLLED STUDY, PARIPEX‾INDIAN JOURNAL OF RESEARCH : VOLUME-6 | ISSUE-7 | JULY-2017


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