Prevalence of thyroid dysfunction in HIV infected patients

Dr. Mahaveer Meena; Dr. Indrajeet Uradiya; Dr. S.R. Meena

Volume : IX, Issue : VII, July - 2020

Prevalence of thyroid dysfunction in HIV infected patients

Dr. Mahaveer Meena, Dr. Indrajeet Uradiya, Dr. S. R. Meena

Abstract :

OBJECTIVE: Thyroid dysfunction in HIV infected patients and correlation with CD4 counts. METHODOLOGY: Prospective study consisting 100 symptomatic HIV seropositive patients were evaluated in our Medical College. Patients with known thyroid disorder, on drugs altering thyroid hormone metabolism, diabetics and pregnancy were excluded from the study. HIV serology was done by ELISA, CD4 count by Flow cytometry and TSH, FT3, FT4 by electrochemiluminescence method. RESULTS: Among the 100 patients, 28 of them had thyroid dysfunction. Subclinical hypothyroidism dominated the type of thyroid dysfunction (57.14%) followed by 35.7% had hypothyroidism. Thyroid dysfunction was highest among HIV patients with CD4 count <200 (37%) followed by CD4 count 200–500 (21.1%), (P=0.045, statistically significant). CONCLUSION: Thyroid dysfunction is frequent in HIV infection and is in direct proportion to the advancing HIV disease (lower CD4 counts). Subclinical hypothyroidism is the commonest dysfunction, with hypothyroidism being next most common.