STUDY OF BENIGN AND MALIGNANT LESIONS OF PROSTATE WITH THEIR HISTOLOGICAL TYPING AND ITS CORRELATION TO PSA LEVEL

Chaitali Gupta; Deepak Mittal

Volume : VIII, Issue : I, January - 2019

STUDY OF BENIGN AND MALIGNANT LESIONS OF PROSTATE WITH THEIR HISTOLOGICAL TYPING AND ITS CORRELATION TO PSA LEVEL

Chaitali Gupta, Deepak Mittal

Abstract :

Background: Prostatic carcinoma is an important growing health problem, presenting a challenge to urologists, radiologists and pathologist1,2. Prostate cancer is the leading cause of new cancer in men and is second only to lung cancer as a leading cause of cancer–related deaths in men3. METHODS: Conventional haematoxylin and eosin (H & E) staining was done in all the 100 cases of benign as well as malignant lesion of prostate and their histological typing was correlated to PSA level. RESULTS: A total of 100 cases were studied, which were in the age group of 50–90 years. Benign prostatic hyperplasia was the commonest lesion. Malignancy was diagnosed in 12 patients and all cases were adenocarcinoma. Benign lesions were having PSA level less than 4ng/ml, while in the patients having carcinoma, the PSA level was up to more than 20ng/ml. CONCLUSION: A strong correlation was found between serum PSA level and tumor diagnosis. Serum PSA level increases with increase of grade of tumor and correlate well with the tumor aggressiveness