Study of the clinical presentation of aplastic anemia with special reference to association with parvovirus B19 infection- A tertiary care hospital based study

Dr. B.C. Kalita; Dr. Alal Uddin; Dr. (Mrs.) S.L. Das; Dr. S. Kar

Volume : VIII, Issue : VII, July - 2019

Study of the clinical presentation of aplastic anemia with special reference to association with parvovirus B19 infection- A tertiary care hospital based study

Dr. B. C. Kalita, Dr. Alal Uddin, Dr. Mrs. S. L. Das, Dr. S. Kar

Abstract :

Aplastic anemia is a disease of bone marrow failure characterized by pancytopenia with marrow hypocellularity. Possible etiologies that have been implicated includes drugs, irradiation and preceding viral infections as non–A, non–B, non–C hepatitis, Epstein Barr virus, cytomegalovirus, HIV and rubella. Most cases of parvovirus B19 infection are asymptomatic or present with ﬂu like symptoms. Severe aplastic anemia has been reported in a previously healthy boy without any underlying diseases, following asymptomatic infection with parvovirus B19. A total of 22 patients with aplastic anemia admitted in medicine ward were studied. Patient with Hb less than 10gm%, total count less than 4000/cumm, platelet counts less than 1, 00,000/cumm were included. Bone marrow aspiration was done in all cases. Serum samples taken from each patient tested for parvovirus antibodies and viral DNA. Parvovirus B19 IgM detected in 22.7% cases and Parvovirus B19 DNA in 18.18% cases