The study of drug interaction of Glipizide with Domperidone on blood glucose level in diabetic mice

Dr Devendra Singh Doneriya; Dr Praveen Gautam

Volume : VII, Issue : VI, June - 2018

The study of drug interaction of Glipizide with Domperidone on blood glucose level in diabetic mice

Dr Devendra Singh Doneriya, Dr Praveen Gautam

Abstract :

Theprokinetic drugDomperidone is used to relievenausea and vomiting, Gastroparesis,Parkinson‘s disease,Functional, dyspepsia,Lactationto increase the transit of food through the stomach (by increasing gastrointestinal peristalsis). Many patients suffering from diabetis mellitus and Domperidonemay be prescribed along with the anti–diabetic agent. Therefore, present work was planned to evaluate drug–drug interaction between Domperidone with glipizide. The study also included evaluation of per se effects of each drug as well as their combinations in alloxan induced diabetic mice.

In this work, we evaluated drug interaction of Domperidone (5 mg/kg p.o.), glipizide (2.5 mg/kg p.o.) and combination of glipizide with Domperidone2.5 + 5 mg/kg, p.o.). The results showed that glipizide reduced blood glucose levels at 2, 3 and 5 hrs period and the difference were statistically significant at 3 and 5 hrs in comparison to control group (p< 0.1). However, statistically significant difference in comparison to glipizide group was observed at 2, and 5 hrs (p<0.01) as the blood glucose reduction was significantly less in comparison to that of the glipizide group. It indicated no acute effect of Domperidone on blood glucose level. However, the combination group (GLP+DOM) produces significant dicrease in blood glucose levels as compared to control group at 2, 3 and 5 hours and results were comparable to that of the glipizide groups. The results showed significant acute variation on blood glucose by Domperidone when given in combination with glipizide. So, the finding of DI of glipizide with Domperidone suggest that acute administration of anti prokinetic drug did affected blood glucose level as well as if it is used as combination with anti diabetic drug glipizide.