Therapeutic response and adverse effects with start - up dose of Ramipril in Essential Hypertension

Dr. Sudhakar M Parhate; Dr. Ashtaputre M D; Dr. Jeswani Dheeraj

Volume : VIII, Issue : VII, July - 2019

Therapeutic response and adverse effects with start - up dose of Ramipril in Essential Hypertension

Dr. Sudhakar M Parhate, Dr. Ashtaputre M D, Dr. Jeswani Dheeraj

Abstract :

Adult patients attending Medicine outpatient department, diagnosed as suffering from essential hypertension were enrolled (n=640) for comparative analysis of starting dose and ADE of Ramipril. The patients with mild HTN were prescribed Ramipril 2.5 mg single dose once a day and those with moderate HTN were prescribed Ramipril 5 mg once a day. These patients were followed weekly at Hypertension clinic for examination and investigations, Cumulative target BP achievement was found at 10th week for mild and 12th week for moderate hypertensive subjects. Dry cough incidence was almost equal in both HTN categories this finding suggest that cough as an ADE of ACEI is independent of type of HTN and dose of drug. Hyperkalaemia incidence appears to follow the grading of HTN and also shows the dose dependent response relationship,other renal function is not affected by Ramipril