WHICH IS THE MOST ACCURATE DIAGNOSTIC PROCEDURE IN TAMOXIFEN TREATED BREAST CANCER PATIENTS?

Volume : VII, Issue : VI, June - 2018

Izzo P. , Pugliese F. , Scarano Catanzaro V. , De Santis A. , Razionale F. , Millarelli F. , Di Cello P. , Izzo S. , Izzo L.

Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi–dimensional (2D) and three–dimensional (3D)

transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in

women treated with tamoxifen (TMX) for east cancer.

Methods: Forty–two patients, affected by east cancer under treatment with TMX, underwent 2D–3D TVUS, HSSG and

hysteroscopy completed by biopsy, after abnormal findings following a routine 2D TVUS examination.

Results: 3D–TVUS was more accurate than 2D–TVUS in the detection of atrophic endometrium confirmed by biopsy and in the

detection of endometrial polyps.

HSSG and hysteroscopy detected atrophic endometrium and endometrial polyps significantly better than ultrasound scan.

Endometrial carcinoma was detected in two cases, and in both HSSG and hysteroscopy were 100% diagnostic.

Conclusion: In TMX treated east cancer patients, HSSG and hysteroscopy provide more accurate diagnosis than 2D–3D

ultrasound in the detection of treatment related endometrial lesions.