Human Immunodeficiency Virus attacks the body’s immune system . Months to years after a person is infected with HIV , the virus destroys all the T lymphocytes . The infections which normally won’t cause severe or fatal disease will eventually cause the death of the HIV patient . AIDS in an adult is defined by the existence of atleast two of the major signs associated with at least one minor sign , in the absence of known cause of immunosuppression such as cancer or severe malnutrition or other recognized etiologies. Aims and objectives To study the blood picture of HIV infected patients ,Analyze specific laboratory determinations of anemias , leukopenia , and thrombocytopenia and correlate with CD4 lymphocyte count .,Identify the clinical manifestations of altered hematopoiesis related to HIV ,To study the bone marrow picture in patients of HIV with pancytopenia . summary The variation in the prevalence of hematological parameters in different stages of diseaseare due to a no of factors which include CD4 count , clinical disease status , drug therapy , opportunistic infections and malignancies ,The most common symptom was fatigue(86%) and fever and the most common signs were pallor and oral thrush ,Among the hematological abnormalitiesanemia was the commonest ,The commonest type of anemia was Normocytic Hypochromic .,Leucopenia was seen in 40% cases whichis statistically significant