A New early diagnostic marker for Adenine Phosphoribosyl Transferase and Xanthine Oxidase deficiency cause uric acid stone formation

Dr. B. Natarajan; Dr. Pratheepa

Volume : VI, Issue : IX, September - 2017

A New early diagnostic marker for Adenine Phosphoribosyl Transferase and Xanthine Oxidase deficiency cause uric acid stone formation

Dr. B. Natarajan, Dr. Pratheepa

Abstract :

Background: The prevalence and incidence of urolithiasis is increasing worldwide. Adenine phosphoribosyl transferase and xanthine oxidase well known to be associated and increases the risk of urolithiasis by altering the composition of urine. The aim of the study was to assess the serum levels of enzymatic markers i.e. Adenine phosphoribosyl transferase and xanthine oxidase deficiency to cause specifically uric acid stone formation and also compared to normal subjects.

Materials and Methods: The study involved two groups. Group A consisted of control (n=30) and Group B consisted of kidney stone patients (n=30). Blood samples were obtained and analysed for Urea, Uric acid, Total Protein, Adenine phosphoribosyl transferase and xanthine oxidase were measured.

Results: We found a significant increase in Adenine phosphoribosyl transferase and xanthine oxidase enzyme activity as compared to normal control subjects.

Conclusion: The data from the present study shows that Adenine phosphoribosyl transferase and xanthine oxidase is altered, and also significantly decreased in uric acid stone patients when compared to normal subjects. This evidence also proves both enzymes are diagnostic marker for uric acid stone patients.