ASSOCIATION BETWEEN PLATELET-LYMPHOCYTE RATIO (PLR) AND NUMBER OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME

Zenith; Rahmad Isnanta; Refli Hasan

Volume : VIII, Issue : VIII, August - 2019

ASSOCIATION BETWEEN PLATELET-LYMPHOCYTE RATIO (PLR) AND NUMBER OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME

Zenith, Rahmad Isnanta, Refli Hasan

Abstract :

Introduction : Acute Coronary Syndrome (ACS) is one of the clinical manifestations of Coronary Heart Disease (CHD) that has high morbidity and mortality. Atherosclerosis is the underlying process of CHD. Inflammation plays an important role in the process of atherosclerosis. Prospective studies suggest that Platelet-to-Lymphocyte ratio (PLR) is one of the predictors of cardiovascular events. Through this study, it is expected to give an illustration of the relationship between PLR value and the number of coronary artery lesions in acute coronary syndrome patients undergoing coronary angiography. Aim : To determine the relationship between PLR value and the number of coronary artery lesions in patients with Acute Coronary Syndrome Methods : This was a observational study of 80 consecutive ACS patients who came to Adam Malik General Hospital Medan, from March to June 2019. Evaluation of PLR value, blood tests, and coronary angiography were performed in each subject. The number of coronary artery lesions were assessed by Vessel Score. Furthermore, the calculated PLR values are associated with Vessel scores using Chi-Square analysis. Results : From 80 research subjects, there were 33 (41.25%) subjects with Simple Vessel Disease (SVD) and 47 (58.75%) subjects with Multi Vessel Disease (MVD). Based on the results of the ROC analysis, it was found that the PLR cut-off point value of the Vessel Score was 109.88 with a sensitivity of 78.7% and specificity of 81.8% with a significant strength (p <0.001). The median of PLR in subjects with SVD was 101.90 (90.67-225.81) while in subjects with MVD was 185.83 (94.74-265.44). In the Chi-Square analysis, there was a significant relationship between PLR value and Vessel score (p <0.001). Conclusion : There is a significant relationship between PLR value and the number of coronary artery lesions in ACS patients.