ASSOCIATION BETWEEN THE EXPRESSION OF MATRIX METALLO PROTEINASE-2 AND COLLAGEN TYPE-III THICKNESS IN FASCIA ENDOPELVIC OF MENOPAUSAL WOMEN WITH PELVIC ORGAN PROLAPSE

M. Rhiza Z. Tala

Volume : VII, Issue : XI, November - 2018

ASSOCIATION BETWEEN THE EXPRESSION OF MATRIX METALLO PROTEINASE-2 AND COLLAGEN TYPE-III THICKNESS IN FASCIA ENDOPELVIC OF MENOPAUSAL WOMEN WITH PELVIC ORGAN PROLAPSE

M. Rhiza Z. Tala

Abstract :

Pelvic organ prolapse (POP) is a disturbing conditions in menopausal women. MMP-2 eak collagen type-III in endopelvic fascia. This study investigate the association between the expression of MMP-2 and collagen type-III thickness in endopelvic fascia of menopausal women with POP. This was a case-control study involved menopausal women who visited Urogynecology unit of Department of Obstetric and Gynecology, Adam Malik General Hospital from July 2017 to the date until the number of minimal sample was achieved. MMP-2 level and collagen type-III thickness were measured from biopsy speciment taken during hysterectomy and blood serum. 45 menopausal women with POP as case group and 47 menopausal women without POP as control group. Negative correlation between the expression of MMP-2 and collagen type-III thickness with r value = 0,638 (close to 0). This study found that higher expression of MMP-2 was associated with lower collagen type-III thickness in fascia endopelvic of menopausal women