Chemotherapy induced early transient febrile neutropenia despite the use of PEGylated Granulocyte Colony stimulating factor

Dr. Vinayak V Maka; Dr Nalini Kilara

Volume : VII, Issue : I, January - 2018

Chemotherapy induced early transient febrile neutropenia despite the use of PEGylated Granulocyte Colony stimulating factor

Dr. Vinayak V Maka, Dr Nalini Kilara

Abstract :

Background: PEGylated Granulocyte – Colony stimulating factor(G-CSF) prophylaxis is given to prevent chemotherapy induced Feile neutropenia and its complications.

Methods: Clinical study included 8 patients aged 30 to 59 years with varied hematologic & solid malignancies on combination chemotherapy. Blood counts are monitored for seven days in patients developing fever after receiving subcutaneous PEGylated G-CSF 6 micrograms.

Results: Six patients developed early feile transient neutropenia after 1st cycle chemotherapy, one after 2nd cycle and one after 4th cycle. Six patients developed feile neutropenia (early & transient) on day 7 post chemotherapy, two on Day 2. Profound neutropenia was found in 7 of the 8 patients. The mean time to recovery was 2.7days [2 to 5 days].

Conclusion: Despite PEGylated G-CSF support, patients can develop early, transient, uncomplicated, reversible neutropenia and fever which tends to recover within mean duration of 2.7days.