Global Journal For Research Analysis (GJRA)

Dr.Sadhana C; Dr.Muthiah N.S

Volume : VI, Issue : III, March - 2017

COMPARISON OF ANTIOXIDANT EFFECT OF GLUTATHIONE AND ASTAXANTHINE IN THEIR THERAPEUTIC RANGE USING IN- VITRO METHODS

Dr. Sadhana C, Dr. Muthiah N. S

Abstract :

Background and Aims:

Combined spinal–epidural (CSE) anaesthesia is being increasingly used for effective post-operative analgesia. This study was designed to evaluate the effect of epidural dexmedetomidine on characteristics of spinal anaesthesia for lower abdominal surgeries.

Methods:

This was a prospective randomised, double-blind, controlled study involving fifty patients belonging to American Society of Anesthesiologists(ASA) Physical Status I and II who underwent surgery were randomly divided into dexmedetomidine( D) group and saline (S) group of twenty five each. All patients received CSE anaesthesia. Ten minutes before subarachnoid block (SAB), Group D received dexmedetomidine1 μg/kg diluted to 5 ml in normal saline (NS) and Group S received NS epidurally. Hyperbaric bupivacaine (15 mg) was administered intrathecally for both groups after epidural injection. Sensory and motor block characteristics, analgesia, sedation and haemodynamics were observed. Statistical analysis was performed using appropriate tests.

Results:

Epidural dexmedetomidine as adjuvant to SAB in CSE produced faster onset and prolonged duration of sensory and motor blockade. There was prolonged duration of analgesia with improved sedation and low pain scores in post operative period in the dexmedetomidine group.

Conclusion:

Administration of dexmedetomidine epidurally, 10 min before SAB, caused early onset and prolonged duration of motor blockade and analgesia, without any significant post-operative complication.