DIFFERENCES OF 25-HYDROXYVITAMIN D SERUM LEVEL BETWEEN LIVER CIRRHOSIS AND HEPATOCELLULAR CARCINOMA PATIENTS IN HAJI ADAM MALIK GENERAL HOSPITAL MEDAN

Handoko Halim; Ratna Akbari Ganie; Gontar Alamsyah Siregar

Volume : VII, Issue : X, October - 2018

DIFFERENCES OF 25-HYDROXYVITAMIN D SERUM LEVEL BETWEEN LIVER CIRRHOSIS AND HEPATOCELLULAR CARCINOMA PATIENTS IN HAJI ADAM MALIK GENERAL HOSPITAL MEDAN

Handoko Halim, Ratna Akbari Ganie, Gontar Alamsyah Siregar

Abstract :

Liver cirrhosis is the third largest cause of death after cardiovascular and cancer. HCC is a liver malignancy that requires early diagnosis. Biological effects of vitamin D include the effects of anti-proliferation, anti-angiogenesis, pro-differentiation, anti-inflammatory, pro-apoptosis, and immunity regulation. Previous studies reported that chronic liver patients had low levels of 25-hydroxyvitamin D. The aim of this study is to differ 25-hydroxyvitamin D serum level between liver cirrhosis and hepatocellular carcinoma patients. Cross-sectional study of 32 consecutive admitted patients in Haji Adam Malik General Hospital Medan from December 2017 to March 2018. Patients were classified as liver cirrhosis and hepatocellular carcinoma patients. Full blood count, hemostasis and liver function test were done. AFP and 25-hydroxyvitamin were measured. Univariate analysis and bivariate were done with SPSS version 24. There was no significant difference between 25-hydroxyvitamin D serum level on liver cirrhosis and hepatocellular carcinoma patients(p = 0.052).