Volume : IV, Issue : X, October - 2015

DOSE AND DURATION DEPENDENT IMPACT OF TRIBUTYLTIN (TBT) ON ATPases OF CHICK BRAIN

Madhavi Thakar, Rahul Kundu

Abstract :

TBT is antifouling agent also categorized under persistent organic pollutant that affects many organs. The present study was designed to assess the dose and duration dependent in vivo toxic effects of TBT on memanebound ATPases like Total, Na+ K+, Ca++, Mg++, Ca++ HCO3-, Mg++ HCO3- ATPases of ain tissue of male chick. Two separate animal groups were exposed by intramuscular administration of 60 and 600 µg kg-1 bw day-1 doses of TBT for continuous 6, 12 and 18 days of exposure durations. Parallel untreated group was also maintained. The results indicated that TBT evoked disturbances in the specific activity of estimated ATPases in various degrees. Although the overall results indicated that different TBT doses did not produce any significant toxic effects on ATPase activity, at the same time significant exposure duration dependent effect was profound in ATPase activity of chick ain.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Madhavi Thakar, Rahul Kundu Dose and Duration Dependent Impact of Tributyltin (TBT) on ATP ases of Chick Brain Global Journal For Research Analysis, Vol: 4, Issue: 10 October 2015

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