Volume : VIII, Issue : VII, July - 2019

Effect of prenatal Olanzapine administration on Brain of Swiss Albino mice

Dr. Soumya Khanna, Dr. Anand Mishra

Abstract :

The women in child beå age group are prone to develop symptoms of mental diseases . These symptoms shouldn’t be ignored as the mental condition can affect the mother and fetus in an adverse way. One such condition is schizophrenia for which Olanzapine is given . This study aims to establish the safety profile of olanzapine when given to pregnant mothers. Materials and methods : Olanzapine was given to pregnant mice in doses of 0.2mg/kg and 2mg/kg whereas tap water was given to control mice from 6th to 12th day of gestation. The female dams were sacrificed on 18th day of gestation by cervical dislocation and fetuses were dissected out by uterotomy. The ain of mice emyos were dissected out, processed and were stained with H&E. Results: On gross examination of ain, the cereum was noticed to be reduced in size in both the treated groups. On histological examination, the cereal cortex of treated mice shows deficient neuroblastic population due to increased necrosis and degeneration of these cells as well as decreased migration of neuroblast to cortical plate which was directly proportional to dose of Olanzapine. Conclusion: Olanzapine causes a dose dependent insult on fetal ain when given to mother during period of organogenesis

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

EFFECT OF PRENATAL OLANZAPINE ADMINISTRATION ON BRAIN OF SWISS ALBINO MICE, Dr.Soumya Khanna, Dr.Anand Mishra GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-7 | July-2019

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