ESTIMATION OF SERUM LIPID PROFILE, SERUM CALCIUM AND ALKALINE PHOSPHATASE AND SERUM PROTEIN IN PATIENTS OF HEAD AND NECK CANCER UNDERGOING RADIOTHERAPY.

Dr. Wajid Ali Shah; Dr. Abhishek Shrivastava; Dr. Varsha Mandloi

Volume : VIII, Issue : I, January - 2019

ESTIMATION OF SERUM LIPID PROFILE, SERUM CALCIUM AND ALKALINE PHOSPHATASE AND SERUM PROTEIN IN PATIENTS OF HEAD AND NECK CANCER UNDERGOING RADIOTHERAPY.

Dr. Wajid Ali Shah, Dr. Abhishek Shrivastava, Dr. Varsha Mandloi

Abstract :

BACKGROUND: Carcinogenesis leads to various biochemical changes in the body. Alteration in the metabolism of lipids may be associated as they have a key role in the maintenance of integrity of cell. Elevated levels of calcium and alkaline phosphatase are frequently observed in advanced cancer. The aim of the study is to evaluate the correlation of serum lipid profile, calcium, alkaline phosphatase and proteins in head and neck cancer patients with histopathological grading and staging. MATERIAL &METHODS: Sixty cases of histopathologically proven carcinoma of oral cavity and oropharynx were analysed. Data were collected and reviewed from the patient�s case files. Patients were analysed for age and sex distribution, tumour staging, metastasis and overall survival. Serum lipid profile and serum levels of calcium, alkaline phosphatase and proteins were evaluated. Statistical analysis was done using chi square test. RESULTS: Decreased LDL-C, HDL-C and VLDL-C levels were observed in head and neck cancer patients. Serum calcium and alkaline phosphatase were not found to be significantly elevated. Serum total protein and albumin levels were decreased. CONCLUSION: Cancer adversely affects the cellular structure and metabolism. We didn�t any significant correlation in the parameters with grading and staging, further studies should be carried out in a large number of patients to conform the role of these parameters with special attention to modifiable parameters in malignancies and their relation with grading and staging of cancer, which could be used as prognostic markers.