Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari; Dr. Subhan Quraishi; Dr. Babita Ghodke

Volume : VI, Issue : XI, November - 2017

Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari, Dr. Subhan Quraishi, Dr. Babita Ghodke

Abstract :

The main objective of the present work was to develop a formulation with increased therapeutic efficacy and improved patient compliance by developing sustained release matrix tablets of water soluble Lamivudine using the mucilage of tamarind seed polysaccharide, fenugreek seeds and gum of black gram seeds to study its functionality as a matrix forming agent for sustained release. Different concentrations of binders like 10%, 20%, and 30% and40% were selected for the study. Compressed tablets were evaluated for hardness, weight variation, friability, thickness and drug content uniformity. The dissolution study proved that the seed mucilage of fenugreek can be used as a matrix forming material for making sustained release matrix tablets of lamivudine. After 12 hours tablets with 20% fenugreek binder showed maximum release (100.82%) and followed zero order kinetics via, diffusion, erosion. The optimized formulation of 20% fenugreek mucilage (F2) was subjected to stability with respect to release pattern.