EXPRESSION OF P63 IN PROSTATIC BIOPSIES

Dr .Divya.J; Dr. Najma R.A; Dr.Suresh.R; Dr. V.Eswari; Dr .V.Banumathy

Volume : V, Issue : XI, November - 2016

EXPRESSION OF P63 IN PROSTATIC BIOPSIES

Dr . Divya. J, Dr. Najma R. A, Dr. Suresh. R, Dr. V. Eswari, Dr . V. Banumathy

Abstract :

Introduction- This study helps us to identify the expression of p63, a new basal cell marker of the present era in prostatic biopsies. Aim- A descriptive study to evaluate the expression of p63 in benign and malignant lesions of prostate. Materials and methods- 35 Prostatic biopsies were collected of which 20 were benign and 15 were malignant. Histopathological evaluation (HPE) was done. These formalin fixed, paraffin – embedded blocks were sliced 3-4 um thickness for Immunohistochemistry (IHC) with p63.The avidin biotin complex detection system was used on specimens of formalin-fixed, paraffin embebbed tissue section. Nuclear staining of basal cells with p63 was taken as positive. Results- Out of 20 benign cases,17 cases showed positivity towards p63 immunostaining and 3showed negative immunostaining.All the15 malignant cases showed negative immunostaining.Conclusion- P63 is found to be expressed in a large majority of benign prostatic lesions and negative in all the cases of prostatic adenocarcinoma.