Volume : VIII, Issue : I, January - 2019

Glucose Effectiveness and Liver Function Enzyme Level in Elderly People

Chun Pei, Shih Wen Kuo

Abstract :

Taiwan is a hyperendemic area of hepatitis. The liver is one of the major organs involved in glucose homeostasis, and abnormal liver function may trigger a vicious cascade of glucose intolerance that eventually leads to type 2 diabetes (T2D). Patients with hepatitis are 4 times more likely to have T2D than the general population. Deterioration of glucose effectiveness (GE) was proposed to be responsible for this relationship. In this study, our goal was to determine the relationship of glutamic pyruvic transaminase (GPT) level with GE in elderly residents of Taiwan. Methods: In 2013 and 2015, from private clinics, we enrolled 19 067 men and 20 798 women (age > 60 years) randomly. Participants were grouped according to GPT level. Scatter plots were constructed and slopes were determined by simple correlation. Results: For both sexes, significant differences were discovered between the patients with and without metabolic syndrome regarding various parameters. Four groups were subsequently defined on the basis of the quartiles of GPT level. The participants with higher GPT level were older and had higher GE. A scatter plot of the correlation between GE and GPT level indicated positive correlation. We further obtained the slopes of the GE in men and women. Conclusion: We identified the negative relationship of GPT level with GE in elderly people of both sexes. No sex difference was discovered. The underlying causal relationship can be determined through longitudinal studies.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

GLUCOSE EFFECTIVENESS AND LIVER FUNCTION ENZYME LEVEL IN ELDERLY PEOPLE, Chun Pei, Shih-Wen Kuo GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-1 | January-2019

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