PSYCHIATRIC DISORDERS IN PATIENTS RECEIVING TREATMENT FOR DRUG RESISTANT TUBERCULOSIS REGISTERED UNDER DR-TB CENTRE IN A TERTIARY CARE HOSPITAL

Dr Rupam Kumar Ta; Dr. Pronoy Sen

Volume : IX, Issue : I, January - 2020

PSYCHIATRIC DISORDERS IN PATIENTS RECEIVING TREATMENT FOR DRUG RESISTANT TUBERCULOSIS REGISTERED UNDER DR-TB CENTRE IN A TERTIARY CARE HOSPITAL

Dr Rupam Kumar Ta, Dr. Pronoy Sen

Abstract :

BACKGROUND The emergence of drug resistant mycobacterium has become a significant public health problem creating an obstacle to effective Tuberculosis (TB) control. Psychiatric disorder can either be induced by treatment regimens or psychosocial factors. Cycloserine administration is frequently reported to be associated with psychiatric disorders. In this study, we have examined the prevalence and characteristics of psychiatric disorders among patients receiving treatment for Drug Resistant TB registered in a tertiary care hospital Aims and Objectives- To evaluate the psychiatric disorders of patients receiving intensive phase treatment of Multi Drug Resistant Tuberculosis (MDR) and Extensively Drug Resistant Tuberculosis (XDR) as per WHO-UMC Causality Assessment Scale. METHODS 76 patients of MDR and XDR Tuberculosis were admitted in DR-TB (Drug Resistant TB) centre, Burdwan Medical College and Hospital and the adverse drug reaction profile particularly the psychiatric symptoms of 2nd line drugs were analysed during the intensive phase for a year after fulfilling the inclusion and exclusion criteria. Treatment was given as per guidelines by Revised National TB Control Program PMDT (Programmatic management of drug-resistant TB). RESULTS Psychiatric disorders were found in 8(10.5%) patients among whom suicidal attempt 3(3.9%) and depression 3(3.9%) were the most common followed by paranoia and hallucination in 1 patient each. CONCLUSIONS The psychiatric reactions were common in the later phase of the regimen and in patients with BMI ≤18. Hence vigilant monitoring is required for these types of patients throughout the course of treatment and sputum smear and culture conversion is very well correlated with clinical and radiological improvement.