Global Journal For Research Analysis (GJRA)

Yi-Lun Chiang; Jin-Biou Chang; Dee Pei; Yen-Lin Chen

Volume : VI, Issue : II, February - 2017

Relationships between ?-glutamyltransferase and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in young adults

Yi Lun Chiang, Jin Biou Chang, Dee Pei, Yen Lin Chen

Abstract :

Type 2 diabetes mellitus (T2DM) is more prevalent in young adults. T2DM affects insulin resistance (IR), glucose effectiveness (GE), and first- and second-phase insulin secretion (FPIS and SPIS, respectively). ϒ-glutamyltransferase (ϒ-GT), an inflammatory marker, is related to IR, but whether ϒ-GT is related to FPIS, SPIS, or GE is unclear. We investigated the associations of ϒ-GT with these four factors. We noted that ϒ-GT positively correlates with IR, SPIS, and FPIS, and negatively correlates with GE in young population without diabetes (18-27 years, 23188 men and 29230 women). GE is most tightly related to ϒ-GT (r = -0.375 for men, r =-0.176 for women). GE should not be overlooked in both sexes.