Global Journal For Research Analysis (GJRA)

Dr. Shushila Kharkwal; Dr. Sanjaya Sharma; Dr. Rajkumar Mishra; Dr. Heena Khan

Volume : VI, Issue : II, February - 2017

Role of antiphospholipid antibody in early pregnancy loss

Dr. Shushila Kharkwal, Dr. Sanjaya Sharma, Dr. Rajkumar Mishra, Dr. Heena Khan

Abstract :

Antiphospholipid anitibodies are a group of autoantibodies that bind to negatively charged phospholipids. These antibodies have been associated with thrombotic events which lead to pregnancy loss. A study was conducted in the Department of obstetrics & gynecology,MLB medical college, Jhansi, to detect and establish a correlation between antiphospholipid antibodies in early pregnancy losses. MATERIAL & METHOD- the study included 70 patients between 16-35 years of age.45 patients were having history of 2 or more spontaneous abortion and 25 patients were having normal obstetrical history. Anticardiolipin antibodies were measured by ELISA method. Both IgG and IgM types of aCL were measured. RESULTS- 3/45 patients were found to be positive for antiphospholipid antibody in group having 3 or more abortions while 0/25 were positive in group having normal obstetric history. CONCLUSION-We concluded that antiphospholipid antibody have association with recurrent abortion(7%) especially during first trimester.