STUDY OF MALIGNANCY OF ORAL CAVITY AND PHARYNX WITH SPECIAL REFERENCE TO ETIOLOGICAL FACTORS AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION

DR. SUMIT RAY; DR. MANOJ SAHA; DR. IRA MONDAL; DR. DEBARATI RAY

Volume : VIII, Issue : VI, June - 2019

STUDY OF MALIGNANCY OF ORAL CAVITY AND PHARYNX WITH SPECIAL REFERENCE TO ETIOLOGICAL FACTORS AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION

Dr. Sumit Ray, Dr. Manoj Saha, Dr. Ira Mondal, Dr. Debarati Ray

Abstract :

Oral cancer holds the eighth position in cancer incidence worldwide, it is the third most common malignancy in South-Central Asia. SCC encompasses at least 90% of all oral malignancies. The hallmark of SCC is its fast and infiltrative growth, invasion and destruction of adjacent structure, and very high potential for metastatic lympho-haematogenous spread. Tumor development is a multi-stage process, angiogenesis is essential to tumor growth and metastasis. We evaluated VEGF expression in tumor tissue in patients with oro-pharyngeal SCC in correlation with local and regional disease relapse, and investigated a relationship between the level of VEGF expression with histological type and tumor grading. Majority of oral and oropharyngeal malignancy were moderately differentiated SCC. VEGF expression was strongly positive in well-differentiated SCC and weakly positive in poorly differentiated SCC.