THE DIFFERENCES OF THE LIPID PROFILE LEVEL IN SUBTYPES OF BREAST CANCER

Mohammad Nazril Rizki; Kamal Basri Siregar; Suyatno

Volume : VIII, Issue : V, May - 2019

THE DIFFERENCES OF THE LIPID PROFILE LEVEL IN SUBTYPES OF BREAST CANCER

Mohammad Nazril Rizki, Kamal Basri Siregar, Suyatno

Abstract :

Background and Aim : Breast cancer is the leading cause of cancer death among woman. Changes in lipid metabolism have been reported in many types of cancer. Lipids have been involved in the regulation of proliferation, differentiation, apoptosis, inflammation, autophagia, motility and memane homeostasis. The purpose of this study is to determine the differences levels of lipid profiles in subtypes of east cancer. Methods: We include all east cancer patients who treated at polyclinics and patient wards of Oncology Surgical Science Department of general hospital of H. Adam Malik Medan since October 2018 to Feuary 2019. Data such as age, age at the onset of menarche, menopausal status, body mass index (bmi), parity status, family history of east cancer, previous history of east cancer, histopathological findings, tumour grade, stage of cancer, genetic subtypes, lipid profile were collected. Results: From 151 patients, The median age of this study was 51.0 (18-82) years. The mean age at the menarche onset was 12.61 (�1.291) years. Patients who were already menopause that represented approximately 78.8% of the total study population. Forty three (28,5%) patients have BMI of 25.0-29.9. Most of the subjects had one to two children around the study period accounting for 53 (35.1%) and 75 (49.7%) patients, respectively. A total of 127 (84%) subjects did not report any history of east cancer occurred in their family members. The results showed that approximately 90% of the subjects had undergone at least one operative management for east cancer. Majority of the samples were categorized as IDC histologic subtypes with 114 (75.5%) patients, poorly differentiated cancer with 87 (57.6%) patients, diagnosed with stage III and IV east cancer which 104 (68.8%) patients, have Luminal A cancer with 81 (53.6%) patients. From the analysis, the only significant finding was for the difference in total cholesterol levels among those with TNBC (p-value of 0.002). Conclusions: There was no difference found in the level of lipid profile as in east cancer subtype. There is a difference in tumor patient TNBC subtype with normal total cholesterol value and abnormal total cholesterol value.