THE EFFECT OF PREOPERATIVE PREGABALIN ON ATTENUATION OF HEMODYNAMIC RESPONSES TO LARYNGOSCOPY & ENDOTRACHEAL INTUBATION

Dr. ANKIT JAIN; Dr. ABHISHEK GUPTA

Volume : VII, Issue : XII, December - 2018

THE EFFECT OF PREOPERATIVE PREGABALIN ON ATTENUATION OF HEMODYNAMIC RESPONSES TO LARYNGOSCOPY & ENDOTRACHEAL INTUBATION

Dr. Ankit Jain, Dr. Abhishek Gupta

Abstract :

Introduction: This study was designed to evaluate the effect of preoperative pregabalin premedication on attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation.

Material and methods: Eighty patients of either sex , belonging to American Society of Anesthesiologists grade 1 and 2 , undergoing elective surgeries under general anesthesia with endotracheal intubation , were randomly assigned to one of the two groups of forty patients each , in a double blinded manner. Group P received pregabalin 150 mg and Group C received placebo orally, one hour prior to induction . The preoperative level of sedation was assessed by the Ramsay sedation scale in the operating room , before induction . Heart rate , systolic blood pressure (SBP) , diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were monitored and recorded as - before and after induction ,immediately after intubation and 1, 3 , 5 minutes after intubation ; thereafter at every 5 minute intervals till end of surgery and also every 15 minutes for 4 hours postoperatively .

Results: Patients in Group P had lower heart rate , SBP, DBP and MAP at all time points suggesting greater hemodynamic stability and better attenuation of the hemodynamic response , when compared with Group C.

Conclusion: Oral pregabalin 150 mg may be accepted as an effective premedication to attenuate hemodynamic responses to laryngoscopy and intubation.