A COMPARATIVE CLINICAL EVALUATION OF INTRAMUSCULAR CARBOPROST TROMETHAMINE WITH INTRAVAGINAL MISOPROSTOL FOR SECOND TRIMESTER TERMINATION OF PREGNANCY.

Dr. Sandhya Jain; Dr. Neeru Malik; Dr. Dolly Chawla; Dr. Benu Gulia; Dr. Sonal Prasad

Volume : VII, Issue : IV, April - 2018

A COMPARATIVE CLINICAL EVALUATION OF INTRAMUSCULAR CARBOPROST TROMETHAMINE WITH INTRAVAGINAL MISOPROSTOL FOR SECOND TRIMESTER TERMINATION OF PREGNANCY.

Dr. Sandhya Jain, Dr. Neeru Malik, Dr. Dolly Chawla, Dr. Benu Gulia, Dr. Sonal Prasad

Abstract :

Objective To comparatively evaluate the success rate of abortion, the induction abortion interval and the side effects associated with intravaginal Misoprostol and intramuscular Carboprost in an endeavour to find safe and effective method for second trimester pregnancy termination.

Material and methods :A prospective randomisednon blinded study conducted in the Department of Obstetricsat Dr Baba SahebAmbedkar Hospital over a period of two years on 60 pregnant women seeking termination of pregnancy between 13 weeks to 20 weeks of gestation.

Results Demographic and Obstetric characteristics of both the groups in terms of age, education, socio economic status,religion, parity, period of gestation and number of previous abortions were similar.Success rate at 24 hours for Misoprostolwas significantly higher than that of Carboprost ( p =0.004) but no statistically significant difference was observed at 48 hours. The mean induction interval was less for misoprostol (12.24 hours) as compared to carboprost (16.82 hours),this difference was statistically significant(p=0.0198). The side effects reported,headache ,nausea vomiting diarhoea and fever were much lower with Misoprostol and the difference was statistically significant.

Conclusion Intravaginal Misoprostolat a dose of 400 mcg 3 hourly is a superior method of termination of second trimester pregnancies in view of its shorter induction abortion interval, fewer side effects and cost effectiveness.