A COMPARATIVE EVALUATION OF ORAL GABAPENTIN AND INTRAVENOUS CLONIDINE PREMEDICATION FOR POSTOPERATIVE ANALGESIA AND ANALGESIC REQUIREMENT FOLLOWING GENERAL ANESTHESIA FOR ABDOMINAL SURGERIES.

Dr. Dhruti Prasad Parida; Dr. Nihar Ranjan Tripathy

Volume : VIII, Issue : VI, June - 2019

A COMPARATIVE EVALUATION OF ORAL GABAPENTIN AND INTRAVENOUS CLONIDINE PREMEDICATION FOR POSTOPERATIVE ANALGESIA AND ANALGESIC REQUIREMENT FOLLOWING GENERAL ANESTHESIA FOR ABDOMINAL SURGERIES.

Dr. Dhruti Prasad Parida, Dr. Nihar Ranjan Tripathy

Abstract :

Introduction : The aim of modern anesthesia is to ensure that patients have surgeries without pain, awake from anesthesia with excellent pain control and to maintain that throughout postoperative period. The major goal in the management of postoperative pain is minimizing the dose of medication, to lessen side effects while still providing adequate analgesia. Aim : To compare the post–operative analgesic efficacy of oral Gabapentin and intravenous Clonidine premedication on patients undergoing abdominal surgeries. Materials & methods : We have undertaken randomized, double blind study of 80 patients undergoing abdominal surgery under general anaesthesia. The study is randomized by closed envelope method. In this 80 envelopes were prepared and were sealed , each containing information about patients administered either Clonidine 1µg/kg intravenous 15 minutes before surgery (Group I) or Gabapentin 300mg orally 2 hours before surgery (Group II). After institutional ethical committee approval, patients undergoing abdominal surgery under general anesthesia of either sex with American Society of Anesthesiologists (ASA) grade I and grade II status posted for elective surgery under general anesthesia were included in the study .The patients were randomly allocated into 2 groups of 40 each ,namely group I and group II. Informed written consents were taken. Data collected in pretested proforma meeting the objectives of the study. Results : In the present study the duration of postoperative analgesic action was observed from time of reversal to first demand of analgesia in the recovery room, which was more in Group II (139.2 ± 31.46 minutes) as compared to Group I (99.62 ± 16.29 minutes) which showed oral Gabapentin was more effective as compared to intravenous Clonidine. Conclusion : In conclusion it can be inferred that oral Gabapentin 300mg can be safely administered 2 hours before elective surgeries for better postoperative analgesia than intravenous Clonidine in abdominal surgeries, without any significant side effect.