A COMPARATIVE STUDY OF EFFICACY OF LETROZOLE VERSUS CLOMIPHENE CITRATE IN OVULATION INDUCTION IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Volume : VII, Issue : V, May - 2018

Dr. Thiripurasundari, Dr. Kaleeswari

Polycystic ovarian syndrome (PCOS) is a complex disorder with heterogeneous clinical and endocrine factors. Incidence in the

reproductive age group is around 20 22%. Ovulation Induction refers to the therapeutic restoration of the release of one egg

per cycle in the woman who either has not been ovulating regularly or has not been ovulating at all.

In letrozole group, 52% of the cases developed single dominant follicle and 15% of the cases had developed two dominant

follicles. In CC group only, 6% of the cases had monofollicular ovulation and 23% of the cases developed two follicles.

Letrozol is more effective in inducing ovulation in patients with an ovulatory cycles than clomiphene citrate in terms of

monofollicular ovulation and a better endometrial thickness than when compared with clomiphene citrate. Letrozole can be

recommended as the first line drug for ovulation induction in an ovulatory patients with polycystic ovarian syndrome.