A COMPARATIVE STUDY OF ORAL PREGABALIN VERSUS GABAPENTIN FOR POST OPERATIVE ANALGESIA IN LOWER LIMB SURGERIES UNDER SPINAL ANAESTHESIA.

Dr.J.VASANTHY; Dr.SANDEEP

Volume : VIII, Issue : VII, July - 2019

A COMPARATIVE STUDY OF ORAL PREGABALIN VERSUS GABAPENTIN FOR POST OPERATIVE ANALGESIA IN LOWER LIMB SURGERIES UNDER SPINAL ANAESTHESIA.

Dr. J. Vasanthy, Dr. Sandeep

Abstract :

BACKGROUND AND AIM: Postoperative pain could be attributed to inflammation resulting from tissue trauma due to surgical incision,tissue injury. This study was done to evaluate and compare the preemptive analgesia efficacy of oral gabapentin vs oral Pregabalin for postoperative analgesia and to assess the adverse effect of the drugs. METHODS: This study is a randomized single blinded prospective study conducted at the tertiary hospital on patients undergoing lower limb surgeries under spinal anaesthesia 90 ASA grade 1 and grade2 patients were allocated into 3 groups, group P–30, group G–30 and group C 30(placebo). The visual analogue scale,Ramsay sedation score and side effects were analyzed using anova ,t test and chi–square test. RESULTS: Pre–emptive pregabalin and gabapentin provide good postoperative analgesia. CONCLUSION: Pregabalin (300mg) provides prolonged pain relief compared to gabapentin(900mg)in the postoperative period. Both drugs have minimal adverse effects.