A COMPARETIVE STUDY OF SALIVARY LACTATE DEHYDROGENASE ENZYME AS AN EARLY BIOMARKER IN ORAL SUBMUCOUS FIBROSIS AND ORAL SQUAMOUS CELL CARCINOMA

Volume : VII, Issue : VI, June - 2018

Dr. Priyanka Kumari Mandia, Dr. Saroj Choudhary

Saliva an important and potential biomarker can be used as an adjuctive step for diagnosing oral cancer and precancers which

improve the prognosis and outcome of the disease process. Aim of this study was To analyse salivary Lactate dehydrogenase level

could be a reliable marker to diagnosis oral submucous fiosis and oral cancer. The present study include150 subjects of either

sex among them:– Group a– 50 healthy control without any clinical symptoms or disease, Group b– 50 Oral submucous fiosis

patients and Group c– 50 Oral squamous cell carcinoma patients. Highly significant increase Salivary lactate dehydrogenase

enzyme leve was found in Oral submucous fiosis and oral squamous cell carcinoma as compared to healthy control. Salivary LDH

level of OSMF patients shows significant difference with Salivary LDH level of OSCC Patients. Mean Salivary LDH level is higher in

OSCC patients. Thus it can be concluded that Salivary lactate dehydrogenase is an early biomarker and supportive diagnostic tool

in oral submucous fiosis and oral squamous cell carcinoma.