A COMPREHENSIVE STUDY TO ASSESS STATUS OF LIVER FUNCTION TESTS IN BETA THALASSEMIC MAJOR PATIENTS IN JHALAWAR MEDICAL COLLEGE JHALAWAR

Dr. Chirag Malik; Dr. Mohammad Hamid

Volume : VIII, Issue : V, May - 2019

A COMPREHENSIVE STUDY TO ASSESS STATUS OF LIVER FUNCTION TESTS IN BETA THALASSEMIC MAJOR PATIENTS IN JHALAWAR MEDICAL COLLEGE JHALAWAR

Dr. Chirag Malik, Dr. Mohammad Hamid

Abstract :

Introduction – Beta thalassemia major patients develop iron overload due to multiple blood transfusionscausing injury to liver indicated by altered liver enzymes. Objective –To study correlation between s. ferritin level and liver enzymes (SGOT, SGPT & ALP) in BTM patients. Material and Methods – Eighty patients of Beta thalassemia major, from Paediatrics ward JMC Jhalawar, were studied for their serum ferritin level and liver enzymes , and statistical analysis was done. Result – Mean values of s. Ferritin, SGOT, SGPT & ALP were 2336.29 +/– 1422.11 ng/ml, 101.26 +/– 49.76 U/L , 95.34 +/– 50.76 U/L , and 193.49 +/– 50.98 U/L . We found positive correlation between s.ferritin and SGOT, SGPT, & ALP. Correlation with SGOT & SGPT was statistically significant. Conclusion – SGOT & SGPT showed positive correlation with serum ferritin (r=0.740 & 0.735 respectively), while ALP was not significantly correlated