A RARE CASE OF ANTI-YO POSITIVE PARANEOPLASTIC CEREBELLAR DEGENERATION (PCD): CASE REPORT

ARINDAM GHOSH; P. PHILO HAZEENA; T. SUGUMAR; S. SUNDAR; V SHANKAR

Volume : VII, Issue : I, January - 2018

A RARE CASE OF ANTI-YO POSITIVE PARANEOPLASTIC CEREBELLAR DEGENERATION (PCD): CASE REPORT

Arindam Ghosh, P. Philo Hazeena, T. Sugumar, S. Sundar, V Shankar

Abstract :

Paraneoplastic cerebellar degeneration (PCD) is a rare entity and can precede the symptoms associated with malignancy by months or years. The most common cancers associated with PCD include Small Cell Lung Cancer, Gynecological, Breast cancers and Lymphomas. Paraneoplastic antibodies manifest as multifocal neurological disease except Anti Yo and Anti Tr antibodies which result in a pure cerebellar syndrome. The clinical presentation is typical of a pancerebellar disorder characterized by appendicular and limb ataxia with speech and gait impairment. Treatment is directed at the cause. A host of immunological therapies have been tried with uncertain efficacy. This report presents a case of paraneoplastic cerebellar degeneration secondary to an infiltrating carcinoma of both easts diagnosed by FDG–PET scan with positive anti–Yo antibodies.